CADD-53. GLIOBLASTOMA TUMORIGENESIS – LESSONS FROM REPRODUCTIVE IMMUNOLOGY
نویسندگان
چکیده
منابع مشابه
Reproductive Rights or Reproductive Justice? Lessons from Argentina.
Argentine sexual and reproductive rights activists insist on using the language and framework of "human rights," even when many reproductive rights activists in the US and elsewhere now prefer the framework of "reproductive justice." Reflecting on conversations with Argentine feminist anthropologists, social scientists, and reproductive rights activists, this paper analyzes why the Argentine mo...
متن کاملTumor-stroma interactions in tumorigenesis: lessons from stem cell biology.
Research in recent years has accumulated a wealth of novel insight into mechanisms by which tumor cells interact with activated fibroblasts, endothelial cells, inflammatory and immune cells and the extracellular matrix. Cancer and stromal cells co-evolve throughout tumorigenesis. As a result, the tumor stroma is now regarded as an essential contributor to tumor establishment, progression and di...
متن کاملLessons in signaling and tumorigenesis from polyomavirus middle T antigen.
The small DNA tumor viruses have provided a very long-lived source of insights into many aspects of the life cycle of eukaryotic cells. In recent years, the emphasis has been on cancer-related signaling. Here we review murine polyomavirus middle T antigen, its mechanisms, and its downstream pathways of transformation. We concentrate on the MMTV-PyMT transgenic mouse, one of the most studied mod...
متن کاملmTOR signaling in glioblastoma: lessons learned from bench to bedside
Phosphatidyl-inositol-3 kinases (PI3Ks) constitute a family of intracellular lipid kinases that are frequently hyperactivated in glioblastoma. The PI3K complex links growth factor signaling with cellular proliferation, differentiation, metabolism, and survival. Mammalian target of rapamycin (mTOR) acts both as a downstream effector and upstream regulator of PI3K, thus highlighting its importanc...
متن کاملFrontiers in reproductive immunology – Forum introduction
It has been 50 years since Sir Peter Medawar kindled scientific interest in the unique problem posed by the existence of the fetal allograft within the uterus [1]. The resultant efforts of immunologists and reproductive physiologists to understand the mechanisms by which the conceptus successfully evades rejection by the maternal immune system has led to a richer understanding of the nature of ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2018
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/noy148.1179